报告题目：Novel Regulation and Function of the Tumor Suppressor PTEN

报 告  人：Dr. Xuejun Jiang， Professor， Memorial Sloan-Kettering Cancer Center

报告时间：12月3日 上午10:30-12:00

报告地点：闵行校区生物药学楼2-116会议室

联 系  人：马小京   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

简介：

Xuejun Jiang教授本科毕业于复旦大学生物化学专业，于1999年获美国Univ. of Texas Southwestern Medical Center药学系博士学位。现任美国Memorial Sloan-Kettering Cancer Center及Cornell University Weill Medical College教授。主要研究方向为: 1. 程序性细胞死亡的分子机制; 2. 肿瘤抑制物PTEN的调控。在Science, Cell, Molecular Cell，Nat Struct Mol Biol.等国际重要期刊发表论文多篇。

主要论文：

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science. 2003 Jan 10; 299(5604):223-6.

Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007 Jan 12;128(1):129-39.

Ganley IG, Wong PM, Gammoh N, Jiang X. Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell. 2011 Jun 24;42(6):731-43. doi: 10.1016/j.molcel.2011.04.024.

Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X. A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell. 2012 Aug 24;47(4):585-95. doi: 10.1016/j.molcel.2012.06.007. Epub 2012 Jul 12.

Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol. 2013 Feb;20(2):144-9. doi: 10.1038/nsmb.2475. Epub 2012 Dec 23.