报告题目：Using Caenorhabditis elegans and Escherichia coli to understand how microbes influence animal ageing

报告人：Dr. David Weinkove

School of Biological and Biomedical Sciences

Durham University,  United Kingdom

报告时间：2012年9月24日上午10:00

报告地点：上海交通大学生物药学楼树华多功能厅

联系人：赵立平  021-34204878

 

Abstract:

The nematode worm C. elegans is a well established model organism used to answer fundamental questions in animal biology. In the lab, C. elegans is cultured on lawns of E. coli, a microbe derived originally from the human gut. We have discovered a mutant of E. coli that extends worm lifespan. This lifespan extension is caused by decreased folate synthesis in microbe. A sulphonamide drug that inhibits E. coli folate synthesis causes a dose-dependent increase in C. elegans lifespan without negative effects on either the microbe or the animal. Thus, this intervention may be transferable to more complex animals to slow ageing and improve health.

 

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